Abstract
THE observation of Woods1, that the anti-bacterial activity of sulphanilamide is inhibited by p-amino-benzoic acid, has been followed from time to time by observations recording a similar anti-sulphanilamide action for other compounds chemically unrelated to p-aminobenzoic acid. Thus Harris and Kohn2 have shown that dl-methionine antagonizes sulphanilamide action. Martin and Fisher3 have reported that adenine possesses anti-sulphanilamide activity in mice infected with streptococci comparable with that possessed by p-aminobenzoic acid. Snell and Mitchell4 found that adenine, guanine, xanthine and hypoxanthine, as well as dl-methionine, reversed sulphanilamide bacteriostasis of certain lactic acid bacteria, although the results were largely dependent on the particular organism and conditions employed. Anti-sulphanilamide action has also been demonstrated with urethane5.
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References
Woods, D. D., Brit. J. Expt. Path., 21, 74 (1940).
Harris, J. S., and Kohn, H. I., J. Pharmacol, 73, 383 (1941).
Martin, G. J., and Fisher, C. V., J. Biol. Chem., 144, 289 (1942).
Snell, E. E., and Mitchell, H. K., Arch. Biochem., I, 93 (1942).
Johnson, F. H., Science, 95, 104 (1942). Mcllwain, H., Science, 95, 510(1942).
Ballard, E., and Johnson, F. H., J. Amer. Chem. Soc., 64, 794 (1942)
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MARTIN, A., ROSE, F. & SWAIN, G. Anti-sulphanilamide Activity of 2-Aminopyrimidine-5-carboxylic Acid. Nature 154, 639 (1944). https://doi.org/10.1038/154639b0
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DOI: https://doi.org/10.1038/154639b0
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