Organic Accelerators for Enzyme Systems


IN order to determine the part played by yeast extracts in the stimulation of the respiration of various cells1, a study was made on the possible antagonism between this respiratory stimulant and several well-known respiratory depressants. The poisons, potassium cyanide, sodium azide, amyl alcohol and urethane, react reversibly or irreversibly with particular enzyme systems of the respiratory chain. Potassium cyanide and sodium azide depress the activity of the iron oxidation catalysts, while amyl alcohol and urethane react with the dehydro-genating system.

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    Cook, E. S., Kreke, C. W., and Nutini, L. G., Studies Inst. Divi Thomae, 2, 23(1938).

  2. 2

    Bancroft, G., and Elliott, K. A. C., Biochem. J., 28, 1911 (1943).

  3. 3

    Von Euler, H., and Josephson, K., Liebigs Ann., 452, 158 (1927).

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KREKE, C., BARTLETT, M. & SUTER, M. Organic Accelerators for Enzyme Systems. Nature 154, 268–269 (1944).

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