Penicillinase from B. subtilis


IN the bacteriological examination of blood or exudates of patients under treatment with penicillin, it is necessary to inactivate any penicillin present if viable penicillin-sensitive organisms are to grow. The routine testing of penicillin products for sterility also requires a means of neutralizing the antibacterial effect of penicillin. The coli-penicillinase method1 has the disadvantages that the preparation is turbid and the activity of the final product varies.

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  1. 1

    Harper, G. J., Lancet, ii, 569 (1943).

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UNGAR, J. Penicillinase from B. subtilis. Nature 154, 236–237 (1944) doi:10.1038/154236b0

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