Metabolism of Acetoacetic Acid in Animal Tissues


BREUSCH1 assumes that acetoacetic and oxaloacetic acids form citric acid in animal tissues according to, the reaction: Wieland and Rosenthal2, apparently independently, arrive at a similar view. They suggest that the following reaction occurs in kidney and heart:

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  1. 1

    Breusch, F. L., Science, 97, 480 (1943).

  2. 2

    Wieland, H., and Rosenthal, C., Liebigs Ann., 554, 241 (1943).

  3. 3

    Krebs, H. A., and Johnson, W. A., Biochem. J., 31, 241 (1937).

  4. 4

    Krebs, H. A., Egglestbn, L. V., Kleinzeller, A., and Smyth, H. D., Biochem. J., 34, 1234 (1940).

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KREBS, H., EGGLESTON, L. Metabolism of Acetoacetic Acid in Animal Tissues. Nature 154, 209–210 (1944) doi:10.1038/154209a0

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