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Growth-Factors Required for the Nutrition of Lactobacillus cosei ɛ


AFTER allowing for the effect of all the then known vitamins of the B complex, investigations by Macrae et al.1 established the presence of another rat growth-factor (factor β) in the amyl alcohol insoluble fraction of acidified liver concentrates. It was shown in Leeds that this factor was essential for the growth of C. diphtheriæ (types intermedius and gravis), and further work on the factor demonstrated its necessity for the growth of L. casei (cf. Chattaway et al.2) and its non-identity with aneurin, riboflavin, pyridoxine hydrochloride, nicotinic acid, choline hydrochloride, calcium pantothenate, inositol and biotin.

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  1. Macrae, T. F., Todd, A. R., Lythgoe, B., Work, C. E., Hind, H. G., and El Sadr, M. M., Biochem. J., 33, 1681 (1939); ibid., 34, 1335 (1940).

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  2. Chattaway, F. W., Happold, F. C., Sandford, Mary, Lythgoe, B., and Todd, A. R., NATURE, 151, 559 (1943).

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  3. Chattaway, F. W., Happold, F. C., and Sandford, Mary, Biochem. J., in the Press.

  4. Pollack, M. A., and Lindner, M., J. Biol. Chem., 147, 183 (1943).

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  5. Mitchell, H. K., Snell, E. E., and Williams, R. J., J. Amer. Chem. Soc., 63, 2284 (1941).

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DOLBY, D., HAPPOLD, F. & SANDFORD, M. Growth-Factors Required for the Nutrition of Lactobacillus cosei ɛ. Nature 153, 619–620 (1944).

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