Letter | Published:

Interrelationship of Vitamins A and E

Nature volume 150, pages 9192 (18 July 1942) | Download Citation



THE effect of vitamin E in preserving vitamin A in oil solution1 and increasing the store of vitamin A in the liver of the rat2 suggests that there is an interdependence of the two vitamins which should become apparent in other ways. The failure of Bacharach3 to confirm all Moore's work on liver storage may be due to differences in condition and relative quantities employed, Moore approximating and Bacharach missing the optimum effect. Using the United States Pharmacopeia vitamin A assay method (with olive oil as the specified “vegetable” oil in the basal diet) and fixed quantities of vitamin A, we have examined the effect of vitamin E over a wide range of dosage on the growth of young rats depleted of vitamin A. Some of the results are summarized in the accompanying graph.

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  1. 1.

    Unpublished data.

  2. 2.

    , Biochem. J. 34, 1321 (1940); , and , NATURE, 147, 794 (1941).

  3. 3.

    , Quart. J. Pharm., 13, 138 (1940).

  4. 4.

    , personal communication.

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  1. (Communication No. 39) Distillation Products, Inc., Rochester, New York, U. S. A.

    • K. C. D. HICKMAN
    • , P. L. HARRIS
    •  & M. R. WOODSIDE


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