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Oxazoline and Thiazoline Rings in Proteins

Nature volume 150, page 57 (11 July 1942) | Download Citation

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Abstract

A STUDY of the O-methylation of wool and silk with methyl bromide and methyl sulphate showed the extent of methylation could not be entirely accounted for as esterification of free carboxyl groups and we suggested that methylation of activated peptide linkages also took place1. We have now obtained evidence suggesting the activated peptide linkages are possibly those which have undergone condensation with the side-chains of Î-hydroxy acids, for example, serine and threonine. By this condensation, oxazoline rings may arise, which Bergmann and Miekeley2, from studies of the reactions of O- and N-benzoylserine, have considered possible constituents of proteins.

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Author information

Affiliations

  1. Wool Industries Research Association, Torridon, Leeds 6. June 16.

    • S. BLACKBURN
    • , W. R. MIDDLEBROOK
    •  & H. PHILLIPS

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DOI

https://doi.org/10.1038/150057a0

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