A DIRECT link with the life and work of Louis Pasteur was severed by the death in Paris of his nephew, Dr. Adrien Loir, on December 16, soon after he had entered his eightieth year. His father, who was professor of chemistry at the University of Lyons, trained him in laboratory technique so that he might help Pasteur in his experimental work. The youth was fortunate in having been chosen by his uncle to accompany him in September 1882 to Bollene in the Department of Vaucluse, where Pasteur and Thuillier, during the next two and a half months, investigated an outbreak of rouget (swine erysipelas). During 1882-88 Adrien Loir assisted Pasteur in the little laboratory in the Rue d'Ulm. This was a notable period in the active life of Pasteur, for it included his researches into the treatment of hydrophobia in man and the prevention of anthrax in domesticated animals.