ACCELERATION OF THE RESPIRATION OF SURVIVING TISSUE

Abstract

THE respiration of tumour tissue in a glucose medium is increased on addition of a suitable indicator (hereinafter called ‘dye’) or dinitro–o–cresol (DNOC), decreased by a narcotic such as phenyl–urethane. I observed in 1936* that when narcotic and dye are added simultaneously, the respiration is only slightly less than with dye alone. On the other hand, the narcotic almost abolishes the acceleration in respiration due to DNOC. The accompanying graphs depict an experiment with the mouse tumour MC 2146 in phosphate–glucose. Similar results were obtained with other concentrations of narcotic, DNOC and dye.

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GREVILLE, G. ACCELERATION OF THE RESPIRATION OF SURVIVING TISSUE. Nature 148, 320–321 (1941). https://doi.org/10.1038/148320a0

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