Abstract
THE respiration of tumour tissue in a glucose medium is increased on addition of a suitable indicator (hereinafter called ‘dye’) or dinitro–o–cresol (DNOC), decreased by a narcotic such as phenyl–urethane. I observed in 1936* that when narcotic and dye are added simultaneously, the respiration is only slightly less than with dye alone. On the other hand, the narcotic almost abolishes the acceleration in respiration due to DNOC. The accompanying graphs depict an experiment with the mouse tumour MC 2146 in phosphate–glucose. Similar results were obtained with other concentrations of narcotic, DNOC and dye.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Greville, G. D., Ph.D. thesis (London, 1939).
Michaelis, H., and Quastel, J. H., Biochem. J., 35, 518 (1941).
Gerard, R. W., Arch. Neural. Psychiat. (Chicago), 40, 985 (1938).
Dickens, F., Biochem. J., 30, 1064 (1936).
Cohen, R. A., and Gerard, R. W., J. Cell. Comp. Physiol., 10, 223 (1937) (table II, p. 229).
Brewer, G., J. Pharmacol., 58, 135 (1936).
De Meio, R. H., and Barren, E. S. G., Proc. Soc. Exp. Biol., 32, 36 (1934).
Greville, G. D., Biochem. J., 30, 877 (1936).
Krahl, M. E., and Clowes, G. H. A., J. Biol. Chem., 111, 355 (1935).
v. Euler, H., and collaborators, Z. Krebsforsch., 49, 46 (1939); Ark. Kemi. Mineral. Geol., 13, Nos. 6 and 8 (1939).
Krebs, H. A., Biochem. J., 34, 775 (1940).
v. Szent-Györgyi, A., "Studies on Biological Oxidation and some of its Catalysts" (Barth, Leipzig, 1937).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GREVILLE, G. ACCELERATION OF THE RESPIRATION OF SURVIVING TISSUE. Nature 148, 320–321 (1941). https://doi.org/10.1038/148320a0
Issue Date:
DOI: https://doi.org/10.1038/148320a0
This article is cited by
-
Blockierung hochaktiver Zellen durch Vitalf�rbung und deren praktische Anwendungsm�glichkeiten
Wilhelm Roux Archiv f�r Entwicklungsmechanik der Organismen (1951)
-
Zur Wirkung von Dinitrokresol und Thiouracil auf den Zellstoffwechsel
Naunyn-Schmiedebergs Archiv f�r Experimentelle Pathologie und Pharmakologie (1950)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
