FLEMING1 noted that the growth of B. coli and a number of other bacteria belonging to the colityphoid group was not inhibited by penicillin. This observation has been confirmed. Further work has been done to find the cause of the resistance of these organisms to the action of penicillin.
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ABRAHAM, E., CHAIN, E. An Enzyme from Bacteria able to Destroy Penicillin. Nature 146, 837 (1940). https://doi.org/10.1038/146837a0
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