Action of Ions on Choline Esterase


THE physiological significance of choline esterase suggested by its high concentration at muscle end plates and at synapses of the central nervous system1 makes it desirable to investigate the properties of the enzyme. The electric organ of Torpedo, which is considered as an accumulation of muscle end plates, has by far the highest content of choline esterase ever found in a tissue of fluid. An organ of 100–200 gm. weight splits about 200–400 gm. acetyl-choline in 60 min., which is a hydrolytic power of the same order of magnitude as calculated for end plates. The organ has therefore been used as material for the preparation of active enzyme solutions2.

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NACHMANSOHN, D. Action of Ions on Choline Esterase. Nature 145, 513–514 (1940).

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