Gattermann Synthesis of Aldehydes


THE observation was made recently that hydrogen cyanide promotes the growth of certain fungi1, which indicates the increased activity of the enzymes present in such circumstances. Earlier findings, on the other hand, had had some bearing on the mechanism of the mixed Cannizzaro reaction2. Investigations are now being carried out in this laboratory, in an attempt to contribute toward the elucidation of the mechanism of the, Gattermann synthesis of aldehydes3.


  1. 1

    Dammann, E., Rotini, O. T., and Nord, F. F., Biochem. Z., 297, 192 (1938). Ergebn. Enzymforschg., 8, 179 (1939).

  2. 2

    Nord, F. F., Beiträge z. Physiol., 2, 301 (1924); Chem. Rev., 3, 65 (1926).

  3. 3

    Gattermann, L., Ber. deut. chem. Ges., 31, 1149 (1898).

  4. 4

    cf., however, Montgomery, E., and Adams, R., J. Amer. Chem. Soc., 46, 1518 (1924).

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MISTRETTA, A., NORD, F. Gattermann Synthesis of Aldehydes. Nature 145, 387 (1940).

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