Cannabidiol and Cannabol, Constituents of Cannabis indica Resin


IN a previous publication, Work, Bergel and Todd1described a method for the separation of cannabinol from Cannabis indica resin (hashish) of Indian origin as its crystalline p-nitrobenzoate. In the course of further work on hashish we have been able, through the co-operation of the Home Office (Drugs Branch), to examine a fresh specimen of the Egyptian drug. Application of the p-nitrobenzoylation process to the distilled resin from this material yielded a less soluble fraction consisting of cannabinol p-nitro-benzoate (in smaller amount than from the Indian drug) mixed with a second ester of much lower melting point. The latter was very difficult to separate and purify; the free phenol obtained from it by hydrolysis was a yellowish resin which, in contradistinction to cannabinol, gave a positive Beam test (purple colour with alcoholic potassium hydroxide).


  1. 1

    Biochem. J., 33, 123 (1939).

  2. 2

    J. Amer. Chem. Soc., 62, 196 (1940).

  3. 3

    Arch. Exp. Path. Pharm., 129, 312 (1928).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

JACOB, A., TODD, A. Cannabidiol and Cannabol, Constituents of Cannabis indica Resin. Nature 145, 350 (1940).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.