Effect of Ultrasonic Vibration on Vaccinia Virus


EARLIER experiments by Hopwood and Gordon1 showed that calf lymph vaccine virus retained its infectivity after subjection to ultrasonic vibrations (c. 500 kilocycles/sec.) and even appeared to have an increased infective titre. The increase was attributed to disengagement of virus from particles of inert material in the crude lymph. Rivers et al.2 found that sonic vibrations of considerably lower frequency (8,900 per second) applied for 15 minutes to purified suspensions of vaccinial elementary bodies resulted in a detectable reduction in their infectivity, and noted that adventitious substances, particularly protein, protected the virus from inactivation.


  1. 1

    Hopwood, F. L., J. Sci. Inst., 6, No. 2, 39 (1929).

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  2. 2

    Rivers, T. M., Smadel, T. F., and Chambers, L. A., J. Exp. Med. 85, 67 (1937).

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  3. 3

    McFarlane, A. S., and Macfarlane, M.G., see preceding letter.

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HOPWOOD, F., SALAMAN, M. & MCFARLANE, A. Effect of Ultrasonic Vibration on Vaccinia Virus. Nature 144, 377 (1939). https://doi.org/10.1038/144377a0

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