EXPERIMENTS on the recovery of synthetic œstrogenic compounds related to stilbene and diphenylethane1 from the urine of female rabbits have shown that the recoveries are very high compared with that of œstrone under the same conditions2. Compounds such as 4:4′-dihydroxy-γ : δ-diphenyl-n-hexane and 4:4′-dihydroxy-α : β-diethylstilbene give recoveries of the order of 20 per cent compared with 1.5 per cent found for œstrone. This indicates a metabolic process for the synthetic œstrogens different from that of œstrone.
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Dodds, E. C., Fitzgerald, M. E. H., and Lawson, W., NATURE, 140, 772 (1937).
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JOURNAL OF HEALTH SCIENCE (2003)
Metabolic Activation of the Proestrogens trans-Stilbene and trans-Stilbene Oxide by Rat Liver Microsomes
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