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A Derived Patterson Analysis of the Skeleton of the Cyclol C2 Molecule

Nature volume 143, pages 648649 (15 April 1939) | Download Citation



RECENT publications by Wrinch1, and in particular by Wrinch and Langmuir2, have suggested that the Patterson analyses obtained by Crowfoot3 for air-dried insulin crystals can be interpreted with some precision if one assumes that the basis of the structure of the insulin molecule is the skeleton of the Wrinch cyclol C2. Criticisms of their work were made by Bernal at a recent meeting of the Physical Society and in a recent letter in NATURE,4. We have done the work reported here in order to answer, if possible two questions. How well do the equivalent points chosen by Wrinch and Langmuir represent the cyclol C2structure ? Does the cyclol fabric give a Patterson diagram resembling the one obtained experimentally ? To do this, the separate atoms of the cyclol skeleton were considered and the appropriate Patterson analysis derived from their interatomic vectors.

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  1. 1.

    , J. Amer. Chem. Soc., 60, 2005 and 3099 (1938).

  2. 2.

    , and , J. Amer. Chem. Soc., 60, 2247 (1938).

  3. 3.

    , Proc. Roy. Soc., A, 164, 580 (1938).

  4. 4.

    , NATURE, 143, 74 (1939).

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  1. Department of Mineralogy, Oxford, and I. Fankuchen, Birkbeck College, London

    • D. P. RILEY


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