Letter | Published:

Diaphorase I and II

Nature volume 143, pages 641642 (15 April 1939) | Download Citation

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Abstract

WE have used the name ‘diaphorase’ to designate the enzyme which catalyses the transport of hydrogen from dihydrocodehydrogenase I (CoH2I) to acceptors like methylene blue or cytochrome, but not to molecular oxygen1,2,3. This enzyme, which had been detected independently by Dewan and Green4 (“coenzyme factor”), occurs in all animal tissues so far examined as well as in yeast5,6 and in higher plants7. Diaphorase from heart muscle, purified to some extent by precipitating a phosphate extract from washed tissues with low concentrations of acetone and ammonium sulphate2, was shown to attack CoH2 I specifically, that is, it was inactive against dihydrocodehydrogenase II (CoH2 II).

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Affiliations

  1. Biochemical Institute, University, Stockholm. Mar. 7.

    • E. ADLER
    • , H. v. EULER
    •  & G. GÜNTHER

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https://doi.org/10.1038/143641b0

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