Letter | Published:

A New Method of the Determination of Saturation by Vitamin C

Nature volume 143, pages 557558 (01 April 1939) | Download Citation



THE only reliable method for determination of the saturation of the living body by vitamin C has so far been that of Tillmann-Harris-Ray. It consists essentially of the daily administration of 300 mgm. of ascorbic acid intravenously, until at least half of this amount reappears in the urine. If the body was saturated, the ejection of this quantity takes place within 1–4 days afterwards. If hypovitaminosis dominates, then the ejection is delayed. So far, by examining blood directly only extreme values can be evaluated: above 1 mgm. per cent indicates saturation, while below 0.4 mgm. per cent indicates hypovitaminosis. Concentrations ranging between cannot be evaluated properly, because 0.5 mgm. per cent may already signify saturation, while in contradistinction 0.9 mgm. per cent may, in certain circumstances, indicate hypovitaminosis.

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  1. Department of Int. Medicine, Count Albert Apponyi Polyclinic, Budapest. Feb. 14.



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