Multiple Activities of Anhydro-oxy-progesterone

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THE introduction of anhydro-oxy-progesterone (pregneninolone, ethinyl-testosterone) by Inhoffen and Hohlweg1 and Ruzicka, Hofmann and Meldahl2, and the demonstration by the former authors of its high progesterone-like activity when given by mouth, opens up the possibility of an important advance in endocrine therapy (see, for example, Zondek and Rozin3); but its multiple biological properties also make the substance of considerable theoretical interest.

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  1. 1

    Inhoffen, H. H., and Hohlweg, W., Naturwiss., 26, 96 (1938).

  2. 2

    Ruzicka, L., Hofmann, K., and Meldahl, H. F., Helv. chim. Acta, 21, 372 (1938).

  3. 3

    Zondek, B., and Rozin, S., Lancet, i, 504, No. 9 (1939).

  4. 4

    McPhail, M. K., J. Physiol., 82, 145 (1934).

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EMMENS, C., PARKES, A. Multiple Activities of Anhydro-oxy-progesterone. Nature 143, 1064 (1939) doi:10.1038/1431064a0

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