Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

OEstrogenic Activity of Certain Synthetic Compounds

Abstract

IN earlier communications1,2 two of us have described the œ"strogenic activity of certain derivatives of diphenylethane, and in particular it was shown that the introduction of an ethylene linkage between the α and β carbon-atoms of such compounds greatly increased the potency. A number of stilbene derivatives were found to possess a marked activity. Following up this observation, the activity of p-hydroxypropylbenzene was next investigated and compared with that of p-hydroxypropenylbenzene (anol). The Å"strogenic activity of some specimens of anol was found to be of a very high order, but further research indicated that this remarkable potency was probably due to the presence of a more complex substance produced as a by-product during the demethylation of anethole3. Recently, the activity of di-anol has been described4.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Dodds and Lawson, NATURE, 139, 627 (1937).

    ADS  CAS  Article  Google Scholar 

  2. Dodds, Fitzgerald and Lawson, NATURE, 140, 772 (1937).

    ADS  CAS  Article  Google Scholar 

  3. Dodds and Lawson, NATURE, 139, 1068 (1937).

    CAS  Article  Google Scholar 

  4. Campbell, Dodds and Lawson, NATURE, 141, 78 (1938).

    ADS  CAS  Article  Google Scholar 

  5. Allan, Dickens and Dodds, J. Physiol., 68, 348 (1930).

    CAS  Article  Google Scholar 

  6. Ramage and Robinson, J. Chem. Soc., 610 (1933).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

DODDS, E., GOLDBERG, L., LAWSON, W. et al. OEstrogenic Activity of Certain Synthetic Compounds. Nature 141, 247–248 (1938). https://doi.org/10.1038/141247b0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/141247b0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing