Letter | Published:

Cytochrome Oxidase

Nature volume 141, page 1101 (18 June 1938) | Download Citation



IN a recent paper on the indophenol oxidase, now known as the cytochrome oxidase, Keilin and Hartree1 repeat the statement which they made in an earlier paper2 that “According to Harrison3, it is hardly necessary even to postulate the existence of an enzyme such as indophenol oxidase. The oxidation of p-phenylenediamine in muscle preparation he explains as a secondary or coupled oxidation by means of a peroxidase or a hæmatin compound acting in conjunction with H2O2 formed in a primary oxidation of substances such as glutathione or hypoxanthine”. They then proceed to give arguments against this secondary oxidation theory, but the facts they quote merely show that the indophenol reaction of tissues is not solely due to secondary oxidation.

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  1. 1.

    , and , Proc. Roy. Soc., B, 125, 171 (1938).

  2. 2.

    , and , Proc. Roy. Soc., B, 119, 114 (1936).

  3. 3.

    , Biochem. J., 23, 982 (1929).

  4. 4.

    , Biochem. J., 25, 1016 (1931).

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  1. Department of Biochemistry, Queen's University, Belfast. May 25.

    • D. C. HARRISON


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