Letter | Published:

The Effect of Enol-Esters of Testosterone

Naturevolume 140pages726727 (1937) | Download Citation



ENOL-ESTERS from the series of male sex hormones were first prepared by L. Ruzicka and W. H. Fischer1, Experiments carried out in our laboratories showed that testosterone diacetate was. less active on the capon's comb than the testosterone monoacetate, but that in single injection (2 mgm.) it was more active than testosterone monoacetate on rats2. Deanesly and Parkes3 recently compared the effect of testosterone monacetate and testosterone diacetate, and the results of their experiments indicated that these In two substances are similar as regards activity. In the meantime, our experiments were extended to the I previously described dipropionate and also to two newly prepared enol-esters of testosterone. The technique corresponds to that earlier described by Miescher, Wettstein and Tschopp4.

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  1. 1

    Ruzicka, L., and Fischer, W. H., Helv. chim. Acta, 19, 806 (1936).

  2. 2

    Ruzicka, L., and Fischer, W. H., Helv. chim. Acta, 19, 1371 (1936).

  3. 3

    Deanesly, R., and Parkes, A. S., Biochem. J., 31, 1161 (1937).

  4. 4

    Miescher, K., Wettstein, A., and Tschopp, E., Biochem. J., 30, 1970, 1977 (1936).

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  1. “Ciba” Research Laboratories, Basle

    • , W. H. FISCHER
    •  & E. TSCHOPP


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