Letter | Published:

Duality of the Coproporphyrins in Bovine Congenital Porphyrinuria

Naturevolume 140pages584585 (1937) | Download Citation



OF the four theoretically possible isomeric types of porphyrins, only those belonging to Series I and III have so far been encountered in Nature. Hæmoglobin, bilirubin, cytochrome, etc., are Series III derivatives. Series III has thus come to be regarded as the normal or physiological type. Excretion of excessive amounts of porphyrins belonging to Series III does, however, occur in certain pathological states including lead poisoning (Grotepass1, Mertens2, Fischer and Duesberg3), pigment cirrhosis of the liver (Dobriner4), hepatic tumours (Dobriner4) and after administration of salvarsan (Schreus5). The uroporphyrin excreted in acute idiopathic porphyrinuria has been shown to be uroporphyrin III (Waldenström6, Mertens7), whilst Dobriner8 has detected the simultaneous presence of coproporphyrins I and III in the stool from one such case.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Grotepass, Z. physiol. Chem., 205, 193 (1932).

  2. 2

    Mertens, Klin. Woch., 16, 61 (1937).

  3. 3

    Fischer and Duesberg, Archiv. expt. Path. Pharm., 166, 95 (1932).

  4. 4

    Dobriner, J. Biol. Chem., 113, 1 (1936).

  5. 5

    Schreus, Klin. Woch., 14, 1717 (1935).

  6. 6

    Waldenström, Deut. Archiv. Klin. Med., 178, 38 (1935).

  7. 7

    Mertens, Z. physiol. Chem., 238, 1 (1936).

  8. 8

    Dobriner, Proc. Soc. Expt. Biol. Med., 35, 175 (1936).

  9. 9

    Fischer and Libowitzky, Z. physiol. Chem., 241, 220 (1936).

  10. 10

    Fischer and Hofmann, Z. physiol. Chem., 246, 15 (1937).

  11. 11

    Rimington, Onderstepoort J. Vet. Sci., 7, 567 (1936).

  12. 12

    Rimington, NATURE, 140, 165 (1937).

  13. 13

    Rimington, forthcoming publication in Comptes Rendus Trav. Lab. Carlsberg: Sörensen Festschrift.

Download references

Author information


  1. Onderstepoort Veterinary Research Laboratory, Pretoria, S. Africa

    •  & G. C. S. ROETS


  1. Search for CLAUDE RIMINGTON in:

  2. Search for G. C. S. ROETS in:

About this article

Publication history

Issue Date




By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.