Letter | Published:

Duality of the Coproporphyrins in Bovine Congenital Porphyrinuria

Nature volume 140, pages 584585 (02 October 1937) | Download Citation

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Abstract

OF the four theoretically possible isomeric types of porphyrins, only those belonging to Series I and III have so far been encountered in Nature. Hæmoglobin, bilirubin, cytochrome, etc., are Series III derivatives. Series III has thus come to be regarded as the normal or physiological type. Excretion of excessive amounts of porphyrins belonging to Series III does, however, occur in certain pathological states including lead poisoning (Grotepass1, Mertens2, Fischer and Duesberg3), pigment cirrhosis of the liver (Dobriner4), hepatic tumours (Dobriner4) and after administration of salvarsan (Schreus5). The uroporphyrin excreted in acute idiopathic porphyrinuria has been shown to be uroporphyrin III (Waldenström6, Mertens7), whilst Dobriner8 has detected the simultaneous presence of coproporphyrins I and III in the stool from one such case.

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Affiliations

  1. Onderstepoort Veterinary Research Laboratory, Pretoria, S. Africa. Aug. 22.

    • CLAUDE RIMINGTON
    •  & G. C. S. ROETS

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DOI

https://doi.org/10.1038/140584a0

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