Letter | Published:

Formation and Breakdown of Amino-acids by Inter-molecular Transfer of the Amino Group

Nature volume 140, pages 503504 (18 September 1937) | Download Citation

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Abstract

WE have previously reported1 the discovery in muscle of a highly active metabolic mechanism, by the action of which the amino group and two hydrogen atoms of glutamic acid are transferred to pyruvic acid (added or of metabolic origin) with the formation of alanine (and ketoglutaric acid). This is the key to the puzzling fact that glutamic acid is transformed into succinic acid by muscle tissue without the formation of either ammonia or amide nitrogen (D. Moyle-Needham).

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References

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    Bull. Biol. et Med. Exper., Moscou, 3, 230 (1937). Biochimia, 2, 242 (1937).

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    and , J. Biol Chem., 107, 505 (1934). , J Amer. Chem. Soc., 58, 2239 (1936).

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    und , Deutsch. Med. Wochenschr., No. 27 (1937).

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Affiliations

  1. Laboratory of Oxidation-Reduction Processes, Department of Metabolic Research, All-Union Institute of Experimental Medicine, Moscow. July 25.

    • A. E. BRAUNSTEIN
    •  & M. G. KRITZMANN

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https://doi.org/10.1038/140503b0

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