Letter | Published:

Choline Esterase in the Central Nervous System

Nature volume 140, page 427 (04 September 1937) | Download Citation

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Abstract

THE theory of transmission of nervous impulses to the voluntary muscles postulates the presence of a high concentration of choline esterase in nerve endings or their neighbourhood1. We have previously demonstrated the accumulation of choline esterase at the end plates of muscle2. We have now compared the rate of hydrolysis of acetylcholine in the grey and white matter of the spinal cord of the dog and found the concentration 10–20 times higher in the grey matter. 100 mgm. grey matter hydrolyse 7–9 mgm. acetylcholine in one hour, while 100 mgrn, white matter split only 0·4–0·9 mgm.

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References

  1. 1.

    , , and , J. Physiol., 87, 394 (1936).

  2. 2.

    , and , C.R. Soc. Biol., 125, 942 (1937).

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Affiliations

  1. Laboratory of General Physiology, University of Paris. July 28.

    • D. NACHMANSOHN

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DOI

https://doi.org/10.1038/140427a0

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