Letter | Published:

Retention of Radioactive Substances in the Body of Rats and the Lethal Dose

Subjects

Abstract

THERAPY by radioactive substances introduced directly into the organism is limited only to a small number of elements, as the use of radioactive salts deposited permanently in the bones proved to be dangerous1. For this reason only two elements have been studied, namely, radon and polonium, with regard to their retention in the organism and quick elimination by means of various vehicles. Experiments were carried out with rats, the weight of which varied from 66 gm. to 290 gm. The present communication deals with the results obtained with radon only. A physiological solution, namely, a 10 per cent solution of glucose or emulsion of tungsten in olive oil, is used as vehicle. The rats received an injection of a maximum dose of 1 c.c. of these substances either subcutaneously or intermuscularly. The solutions were activated with radon in such a manner that the activity of one injection was 0·5–14 millicuries. The rate of elimination of radon from the body of the rats was measured electrometrically by the method of gamma rays of the active deposit of radon.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Summarized report: Evans, R. D., Amer. J. Public Health, 23, 1017 (1933); Laborde, S., Presse méd., Nr. 95 (1936).

Download references

Author information

Rights and permissions

To obtain permission to re-use content from this article visit RightsLink.

About this article

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.