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Inactivation of Vaccinia Virus by Ascorbic Acid and Glutathione


JUNGEBLUT and his co-workers1 have shown that the virus of poliomyelitis and diphtheria toxin were inactivated by ascorbic acid. One of us2 has shown that addition of ascorbic acid to cultures of C. diphtheri” leads to production of relatively atoxic filtrates. Further studies on the nature of this interaction established a reasonable presumption that there was an oxido-reduction between the ascorbic acid and toxophore group of diphtheria toxin.

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  1. Jungeblut, C. W., J. Exp. Med., 62, 517 (1935); Jungeblut, C. W., and Zwemmer, R. L., Proc. Soc. Exp. Med. and Biol., 32, 1229 (1935).

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  2. Kligler, I. J., NATURE, 138, 291 (1936).

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KLIGLER, I., BERNKOPF, H. Inactivation of Vaccinia Virus by Ascorbic Acid and Glutathione. Nature 139, 965–966 (1937).

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