Figure 1 | Neuropsychopharmacology

Figure 1

From: The Corticosteroid Receptor Hypothesis of Depression

Figure 1

Munich Vulnerability Study. Seventy-five healthy probands selected from families with a high genetic load for depression (high risk probands, HRP) received 100 μg human CRH (i.v.) at 15:00 h after pretreatment with an oral dose of 1.5 mg dexamethasone at 23:00 h the day before. The plasma cortisol response (adjusted means ± SEM; adjusted by age and sex) of the HRPs, matched patients with major depressive episode (MDE) and matched healthy controls (CP) from families without history for psychiatric morbidity were found to be significantly (F2,129 = 16.36, p < .001) different. (Adapted from Holsboer et al. 1995 and additional data).

Back to article page