Table 1 Relative 2-DG Uptake in Response to Ketamine, MK-801, and Amphetamine

From: Effects of Ketamine, MK-801, and Amphetamine on Regional Brain 2-Deoxyglucose Uptake in Freely Moving Mice

Brain regions Saline ( n = 5) Ketamine (30 mg/kg) ( n = 6) MK-801 (0.3 mg/kg) ( n = 4) MK-801 (0.5 mg/kg) ( n = 4) Amphetamine (4 mg/kg) ( n = 7)
Medial prefrontal cortex 1.53 ± 0.08 1.88 ± 0.08* 1.71 ± 0.16 1.95 ± 0.07* 1.63 ± 0.06
Ventrolateral orbital cortex 1.64 ± 0.12 1.90 ± 0.10 1.67 ± 0.07 1.96 ± 0.07* 2.01 ± 0.14*
Nucleus accumbens 1.50 ± 0.09 1.93 ± 0.15* 1.73 ± 0.05 1.91 ± 0.11* 1.56 ± 0.08
Caudate putamen 1.86 ± 0.03 2.42 ± 0.09* 2.04 ± 0.06 2.30 ± 0.24* 1.96 ± 0.09
Cingulate cortex 1.74 ± 0.15 2.15 ± 0.12* 1.74 ± 0.08 2.27 ± 0.20* 2.06 ± 0.13
Retrosplenial cortex 1.70 ± 0.13 2.05 ± 0.06* 1.84 ± 0.10 2.18 ± 0.18* 1.99 ± 0.08
Medial septal nucleus 1.68 ± 0.17 1.70 ± 0.06 1.63 ± 0.18 1.86 ± 0.04 2.26 ± 0.14*
Globus pallidus 1.63 ± 0.09 1.71 ± 0.05 1.73 ± 0.11 1.67 ± 0.09 1.61 ± 0.09
Anterior ventral thalamic nucleus 2.16 ± 0.07 2.73 ± 0.14* 2.44 ± 0.04* 2.69 ± 0.07* 2.50 ± 0.12*
Lateral dorsal thalamic nucleus 2.07 ± 0.06 2.26 ± 0.01 2.20 ± 0.17 2.44 ± 0.11* 2.69 ± 0.14*
Medial dorsal thalamic nucleus 1.87 ± 0.05 2.06 ± 0.06 1.94 ± 0.20 2.50 ± 0.08* 2.42 ± 0.06*
Ventral medial thalamic nucleus 1.97 ± 0.03 2.09 ± 0.09 2.11 ± 0.20 2.33 ± 0.09* 2.46 ± 0.11*
Subthalamic nucleus 1.63 ± 0.21 1.93 ± 0.17 1.90 ± 0.10 1.82 ± 0.08 2.51 ± 0.09*
Medial geniculate nucleus 1.81 ± 0.27 1.54 ± 0.15 1.41 ± 0.12 1.73 ± 0.07 2.09 ± 0.13
Basolateral nucleus of the amygdala 1.48 ± 0.08 1.75 ± 0.02* 1.81 ± 0.60* 1.87 ± 0.12* 1.48 ± 0.07
Hippocampus, CA-1 stratum radiatum 1.31 ± 0.03 1.25 ± 0.05 1.34 ± 0.07 1.33 ± 0.13 1.35 ± 0.07
Hippocampus, CA-3 stratum radiatum 1.37 ± 0.07 1.43 ± 0.08 1.61 ± 0.11 1.64 ± 0.07* 1.47 ± 0.14
Stratum lacunosum moleculare (rostral) 1.63 ± 0.11 2.18 ± 0.07* 2.02 ± 0.12* 2.52 ± 0.08* 1.77 ± 0.07
Stratum lacunosum moleculare (caudal) 1.46 ± 0.12 2.43 ± 0.28* 2.05 ± 0.04* 2.20 ± 0.18* 1.58 ± 0.09
Anterior pretectal nucleus 1.73 ± 0.20 1.78 ± 0.18 1.65 ± 0.32 1.76 ± 0.07 2.55 ± 0.11*
Substantia nigra (reticular) 1.45 ± 0.15 1.43 ± 0.09 1.36 ± 0.07 1.50 ± 0.10 1.50 ± 0.04
Substantia nigra (compact) 1.50 ± 0.17 1.52 ± 0.20 1.38 ± 0.13 1.36 ± 0.12 1.63 ± 0.06
Inferior colliculus 1.52 ± 0.08 1.39 ± 0.05 1.31 ± 0.13 1.43 ± 0.08 1.60 ± 0.24
  1. Data are means ± S.E.M. and expressed as ratios of optical density in gray matter regions relative to that in the corpus callosum. Significantly different compared to the saline group.
  2. *p < .05.