A Case of Complete Reversion of a Chromosomal Rearrangement in Drosophila melanogaster

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THE process of gene mutation is known to be reversible, since back-mutations occur both spontaneously and under X-ray treatment. Yet no authenticated case of a complete reversal of a gene rearrangement has hitherto been observed. Muller and Stone1 induced a partial re-inversion of the ClB-inversion of the X-chromosome, but neither of the new breaks corresponded to the original ClB breaks. A spontaneous re-inversion of the same inversion observed by Gershenson2 has not been completely analysed ; so it remains doubtful whether in this case old and new breaks coincided precisely.

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  1. 1

    H. J. Muller and W. S. Stone, Anat. Record, 47 (1930).

  2. 2

    S. Gershenson, Drosophila Information Service, No. 1 (1934).

  3. 3

    Hans Gruneberg, J. Genetics, 31, 163 (1935).

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