Abstract
THE inhibitory effect of phloridzin on phosphatase action1 is well pronounced only when rather high concentrations (about m/50-m/100) of the poison are used. The phloridzin concentrations which are able to prevent any reabsorption of glucose in the kidney are definitely lower2 (about 0·5-1 mgm. per gm. kidney). Phloridzin is hydrolyzed by N hydrochloric acid at 100° into glucose and phloretin.
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References
Lundsgaard, Biochem. Z., 264, 209 (1933).
Lundsgaard, Skand. Arch. Physiol., 72, 265 (1935).
Lambrechts, Compt. rend. Soc. boil., 121, 870 (1936).
Hoffmann, Biochem. Z., 285, 429 (1936).
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KALCKAR, H. Inhibitory Effect of Phloridzin and Phloretin on Kidney Phosphatase. Nature 138, 289 (1936). https://doi.org/10.1038/138289b0
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DOI: https://doi.org/10.1038/138289b0
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