Abstract
SOME new facts have been found suggesting that the first stage in the biological oxidation of carbohydrate is its conversion to glucose-6-phosphoric acid (or Robison ester), which is oxidized1 to 6-phospho-gluconic acid. Dehydrogenation by a specific dehydrogenase co-enzyme system yields 6-phospho-ketogluconic acid, probably the 2-keto acid, which is then decarboxylated. In animal tissues, where there is evidence2 that decarboxylation is oxidative, phospho-arabonic acid would result. Yeast carboxylase, which converts keto-acids to aldehydes, would yield arabinose phosphate, as recently suggested by Lipmann3. Further oxidation to the 3-carbon systems would then consist in a repetition of these reactions.
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References
Warburg, Christian and Griese, Biochem. Z., 282, 157 (1935).
Weil-Malherbe, NATURE, 138, 551 (1936); Chem. and Ind., 55, 838 (1936).
Lipmann, NATURE, 138, 588 (1936).
Green and Brosteaux, Biochem. J., 30, 1489 (1936).
Axmacher and Bergstermann, Biochem. Z., 272, 259 (1934).
Warburg and Christian, Biochem. Z., 237, 440;(1936).
Theorell, NATURE, 138, 687 (1936).
Dickens and Weil-Malherbe (unpublished).
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DICKENS, F. Mechanism of Carbohydrate Oxidation. Nature 138, 1057 (1936). https://doi.org/10.1038/1381057a0
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DOI: https://doi.org/10.1038/1381057a0
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