Abstract
Magnetic resonance imaging and positron emission tomography with fluorodeoxyglucose (FDG) were used to study the size and metabolic rate of eighteen schizophrenics, primarily never medicated, and eighteen normal controls. All subjects performed a CPT (Continuous Performance Task) during the FDG uptake period. The cerebellar region of interest was determined using a semi-automated computer algorithm on the MRI images. These outlines were superimposed on the matching PET scan images. The posterior and anterior cerebellar regions in the schizophrenic group were larger compared to the control group. In addition, the patients had lower relative glucose metabolic rates. Cerebellar area and glucose metabolism negatively correlated with the total brief psychiatric rating scale (BPRS) scores and the emotional withdrawal, conceptual disorganization and mannerism subscales. These results are suggestive of cerebellar dysfunction in schizophrenia.
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Luu, C., Teng, C., Shihabuddin, L. et al. Magnetic Resonance and Positron Emission Tomography Imaging of the Cerebellum in Schizophrenia. Neuropsychopharmacol 11, 275 (1994). https://doi.org/10.1038/sj.npp.1380175
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DOI: https://doi.org/10.1038/sj.npp.1380175