Abstract
WE have reported that we were unable to obtain any evidence of ” strogenic activity in rats with benzylidenepyruvic acid and furylidenepyruvic acid or their sodium salts1. These negative results were attributed by Friedmann2 to the use of insufficient doses (100 mgm. per rat), and to an unsuitable spacing of the doses. Friedmann predicted that 240 mgm. of dry sodium salts would be sufficient to produce ” strus in rats, and claimed to have obtained ” strus in mice with 24 mgm., injected in three doses at intervals of 24 hours.
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References
J. W. Cook and E. C. Dodds, NATURE, 135, 959; 1935.
E. Friedmann, NATURE, 136, 108; 1935.
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COOK, J., DODDS, E. & WARREN, F. Chemistry of strogenic Substances. Nature 136, 912–913 (1935). https://doi.org/10.1038/136912b0
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DOI: https://doi.org/10.1038/136912b0
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