Letter | Published:

Mixed Agglutination


IF a mixed suspension of sheep erythrocytes and a certain strain of Friedländer bacilli are made to agglutinate in the presence of both homologous antisera, what appears to be a novel form of agglutination—mixed agglutination—is observed. The clumps obtained under our conditions by thus simultaneously mixing two antigens and their antibodies in the same system are seen to consist not only of red cells adherent to red cells, and not only of bacilli adherent to bacilli, but also of bacilli and red cells adherent to one another. Control experiments with only one antiserum do not yield the mixed clumps, although occasionally a red cell or two may be seen adherent to the specifically agglutinated organisms, and vice versa.

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