Letter | Published:

Chemistry of strogenic Substances

Naturevolume 135page959 (1935) | Download Citation



IN view of the results published by E. Friedmann in NATURE of April 20, we decided to investigate the effect upon ovariectomised rats of the two compounds specifically mentioned by him as “strogenic, namely, sodium benzylidenepyruvate and sodium furylidene-pyruvate. These were prepared and purified exactly as described by Friedmann1. They were dissolved in water, the strength being 100 mgm. in 3 c.c., and administered in 6 doses of 0·5 c.c., each compound being injected into 5 rats. The technique employed was that described in the paper by Allan, Dickens and Dodds2.

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  1. 1

    Friedmann, E., Helv. Chim. Acta, 14, 783; 1931.

  2. 2

    Allan, H., Dickens, F., and Dodds, E. C., J. Physiol., 68, 348; 1930.

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  1. Research Institute, The Cancer Hospital (Free), London, S.W.3

    • J. W. COOK
  2. Courtauld Institute of Biochemistry, Middlesex Hospital, London, W.1

    • E. C. DODDS


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