Letter | Published:

Mechanism of Respiration

Nature volume 135, page 305 (23 February 1935) | Download Citation

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Abstract

THE respiration of the minced breast muscle of the pigeon has been studied by means of specific poisons (malonic, maleic and arsenious acid). Experiments show that in the main process of respiration, no substances other than succinic acid and its first oxidation product, fumaric acid and the hydrate of the latter, malic acid, are oxidised directly by the Warburg-Keilin Atmungsferment-Cytochrom system. Both succinic and malic acids are activated by the corresponding specific dehydrogenase. Only these two dehydrogenases seem to be connected immediately with the Warburg-Keilin system. Succinic acid is oxidised by them to fumaric, malic to hydroxy-fumaric acid. Both oxidations are reversible.

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  1. Institute of Medical Chemistry, Szeged. Jan. 26.

    • A. SZENT-GYÖRGYI

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DOI

https://doi.org/10.1038/135305b0

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