Letter | Published:

Synthetic Compound with Vitamin B2 Activity

Nature volume 135, page 185 (02 February 1935) | Download Citation



ACCORDING to a note1 in NATURE on a lecture recently given by me, synthetic 6.7-dimethyl-9-l-araboflavin, C17H20N4O6, possesses similar growth-promoting activity to that of lactoflavine (vitamin B2). The statement, that a catalytically active compound results by combination with the colloidal carrier of the yellow enzyme of O. Warburg and W. Christian is incorrect, both for the natural and synthetic pigment, in so far as experiments in vitro are concerned. According to the in vitro experiments described by H. Theorell2, phosphoric acid plays an important role in the combination. In vivo, on the other hand, a combination of both pigments with phosphoric acid and protein to form yellow enzymes apparently takes place. In this sense only3 does the synthesis of a compound with vitamin B2 activity represent also the first synthesis of the active group of an enzyme.

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  1. 1.

    NATURE, 134, 966; 1934.

  2. 2.

    Biochem. Z., 275, 37, 344; 1934.

  3. 3.

    For the original German text, see Ber., 67, 2084; 1934. 68, 166; 1935.

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  1. Kaiser Wilhelm-Institut, Heidelberg. Jan. 9.



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