Letter | Published:

Actiori of Phenyl Isocyanate on Insulin

Nature volume 134, page 290 (25 August 1934) | Download Citation

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Abstract

DURING the past three years, we have been investigating the properties of proteins which have been treated with phenyl isocyanates1. This reaction is of special value for the introduction of new groups into proteins, since it is rapid and can be carried out in neutral or faintly alkaline solution (pH. 7–8) and at relatively low temperatures (5°–8° C.).

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References

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    , and , Biochem. J., 27, 740 and 1706; 1933. 28, 228; 1934.

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    , and , J. Biol. Chem., 98, 281; 1932;

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    Science, 75, 614; 1932.

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Author information

Affiliations

  1. Department of Physiology, University of Leeds. July 11.

    • S. J. HOPKINS
    •  & A. WORMALL

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DOI

https://doi.org/10.1038/134290a0

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