Letter | Published:

Vitamin B2 and the Pellagra-like Dermatitis in Rats

Naturevolume 133pages498499 (1934) | Download Citation



IN our first experiments on the concentration and isolation1 of vitamin B2, we failed to observe definite changes in the skin and fur, such as those described by J. Goldberger and R. D. Lillie2, and by H. Chick and M. H. Roscoe3 and several other authors, in rats fed on diets containing the antineuritic vitamin in a purified form (for example, alcoholic extracts of wheat or maize, Peters's antineuritic concentrate from yeast, crystalline vitamin B1 preparations). The flavin pigment was identified by us with vitamin B2 by its growth-promoting properties. It was therefore a question for further investigation whether in these circumstances it was also identical with the anti-dermatitis factor and in particular with the pellagra preventing factor.

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  1. 1

    P. György, R. Kuhn, and Th. Wagner-Jauregg, Naturwiss., 560; 1933. Klin. Wschr., 1241; 1933. Z. physiol. Chem., 1934.

  2. 2

    Public Health Rep. Wash., 41, 1025; 1926.

  3. 3

    Biochem. J., 21, 698; 1927.

  4. 4

    cf. M. Kellog and W. H. Eddy, Science, 33, 609, Dec. 29, 1933.

  5. 5

    J. Amer. Chem. Soc., 53, 3501; 1931.

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    Biochem. J., 23, 498; 1929.

  7. 7

    Biochem. J., 27, 225; 1933.

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  1. Physiological and Nutritional Laboratories, University of Cambridge



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