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Nature of Antibodies


IT was found by Breinl and Haurowitz1 that when proteins of an agglutinating serum had been coupled with diazotised atoxyl (p-amino-benzene-arsinic acid), the agglutinating power of the serum was not wholly lost. In this process, the proteins are themselves converted into azo-dyes, but the products are not strongly coloured. If, however, benzidine is tetrazotised, and coupled to R salt and to the serum proteins, according to the method of Heidelberger, Kendall and Soo Hoo2, a deep red compound is formed, and the agglutinin again is not wholly destroyed.

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  1. Breinl, F. and Haurowitz, F., Z. Immun. Forsch., 77, 176 ; 1932.

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  2. Heidelberger, M., Kendall, F. E. and Soo Hoo, C. M., J. Exp. Med., 58, 137 ; 1933.

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MARRACK, J. Nature of Antibodies. Nature 133, 292–293 (1934).

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