Abstract
WHILST it has been known since 1885 that certain nitrophenols can cause a remarkable increase in the metabolism of the whole animal, the mechanism of this action is still little understood. Experiments with perfused limbs led Magne, Mayer and Plantefol1 to the view that 1:2:4-dinitrophenol (thermol) causes a direct stimulation of cellular oxidations with increased carbohydrate consumption. Proof of this idea is now given by the experiments described below, in which it is shown that a nitrophenol can cause a large increase in the respiration of thin slices of surviving rat tissue when added in suitable concentration to the medium in which they are respiring.
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References
Ann. Physiol, 8, 1; 1932.
Biochem. J., 25, 973; 1931.
Lancet, Aug. 12, 1933, p.352.
J. Exp. Med., 52, 447; 1930.
Naturwiss., 20, 171; 1932.
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DODDS, E., GREVILLE, G. Acceleration of Tissue Respiration by a Nitrophenol. Nature 132, 966–967 (1933). https://doi.org/10.1038/132966b0
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DOI: https://doi.org/10.1038/132966b0
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