Table 3 Single Marker P-Values for Alcohol- and Nicotine-Dependent Families as Well as for the Combined Family Sample

From: Association of DNA Polymorphisms in the Synaptic Vesicular Amine Transporter Gene (SLC18A2) with Alcohol and Nicotine Dependence

  Alcohol-dependent families Nicotine-dependent families Alcohol+nicotine-dependent families
Marker P -value a Affected b Unaffected b P -value a Affected b Unaffected b P -value a Affected b Unaffected b
rs363387 0.0325 0.9828 0.9416 0.3883 0.9739 0.9579 0.0190 0.9787 0.9490
rs363390 0.1122 0.7574 0.8249 0.3634 0.7395 0.7847 0.0717 0.7496 0.8067
rs363333 0.0066 0.9619 0.8904 0.6050 0.9635 0.9527 0.0078 0.9623 0.9182
rs363343 0.4018 0.8454 0.8809 0.3878 0.7865 0.8429 0.1972 0.8194 0.8637
rs929493 0.6868 0.8493 0.8673 0.3834 0.7917 0.8473 0.3137 0.8237 0.8584
rs1890404 0.5634 0.8596 0.8846 0.3776 0.8021 0.8534 0.2563 0.8344 0.8708
rs363236 0.5420 0.8504 0.8728 0.1335 0.8511 0.8873 0.1151 0.8507 0.8792
  1. aP-values have been obtained using the FAMHAP program and are based on 10 000 simulations. Bold values represent P-values <0.05.
  2. bFrequency estimates for ‘affected’ are based on the frequency in a single affected offspring per family, frequency in ‘unaffected’ is calculated from the nontransmitted alleles to a single affected offspring per family; frequencies are given for the common allele.