Table 1 Effects of NAC on Reduction of DAT and DA D1 Receptors in the Monkey Striatum after Administration of MAP

From: Protective Effects of N-acetyl-L-cysteine on the Reduction of Dopamine Transporters in the Striatum of Monkeys Treated with Methamphetamine

  Control MAP
Monkey-1   
 DAT 3.563 (100%) 1.022 (28.7%)
 DA D1 1.824 (100%) 1.678 (92.0%)
Monkey-2   
 DAT 3.255 (100%) 1.025 (31.5%)
 DA D1 1.836 (100%) 1.927 (105%)
Monkey-3   
 DAT 4.827 (100%) 1.700 (35.2%)
 DA D1 2.272 (100%) 2.171 (95.6%)
DAT (mean±SEM) 3.882±0.481 (100%) 1.249±0.226 (31.8±1.88%)*
DA D1 (mean±SEM) 1.977±0.147 (100%) 1.925±0.142 (97.5±3.88%)
  Control NAC+MAP
Monkey-4   
 DAT 4.269 (100%) 2.648 (62.0%)
 DA D1 2.780 (100%) 2.587 (93.1%)
Monkey-5   
 DAT 2.649 (100%) 1.696 (64.0%)
 DA D1 1.680 (100%) 1.788 (106%)
Monkey-6   
 DAT 2.524 (100%) 1.743 (69.1%)
 DA D1 1.742 (100%) 1.667 (95.7%)
DAT (mean±SEM) 3.147±0.562 (100%) 2.029±0.310 (65.0±2.11%)*,#
DA D1 (mean±SEM) 2.067±0.357 (100%) 2.014±0.289 (98.3±3.94%)
  1. Values of binding potential are shown.
  2. *P<0.05 as compared with the control group (a paired t-test).
  3. #P<0.001 as compared with the MAP-treated group (a unpaired t-test).