Abstract
ONE of the most satisfactory features of recent advances in the X-ray analysis of compounds of high molecular weight has been the degree of co-ordination between the efforts of the structure analyst and those of the chemist. Especially is this true in the case of investigations of the structure of cellulose and its derivatives. The question of protein structure, however, appears to bring in its train problems of quite another order of complexity, and it does not seem to be at all clear what is connoted by the phrase ‘molecular weights of proteins’. Such X-ray photographs of fibrous proteins as have been obtained point to the periodic repetition of comparatively simple units with imperfect or variable side-linkages. In the quest for chemical data to correlate with these results, the crystallographer is at once brought up against the remarkable observations of Svedberg, that there are groups of soluble proteins of ‘molecular weights’ which are simple multiples of 34,500. The present situation is most simply described by quotations from two recent letters 1, 2 to NATURE:—
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
C. Rimington, NATURE, 127, 440; 1931.
T. Svedberg, NATURE, 127, 438 ; 1931.
W. T. Astbury and K. Yardley, Phil. Trans. Roy. Soc., A, 224, 221 ; 1924. (See Hate 5 (1), (7), Plate l6 (144), Plate 18 (157 and 158).)
T. Svedberg, Trans. Faraday Soc., "General Discussion on Colloid Science applied to Biology"; 741 ; 1930.
W. T. Astbury, J. Soc. Chem. Ind., 49, 441 ; 1930: J. Textile Science, 4, 1 ; 1931. W. T. Astbury and H. J. Woods, NATURE, 126, 913 ; 1930. W. T. Astbury and A. Street, Phil. Trans. Boy. Soc., A, 230, 75 ; 1931.
R. Brill, Ann. Chem., 434, 204 ; 1923. K. H. Meyer and H. Mark, Ber., 61, 1932 ; 1928. O. Kratky, Z. phys. Chem., B5, 297 ; 1929.
J. B. Speakman, Proc. Roy. Soc., B, 103, 377 ; 1928.
J. B. Speakman, Trans. Farad. Soc., 25, 169 ; 1929.
J. Hengstenberg and H. Mark, Zeit. f. Krist., 69, 271 ; 1928.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ASTBURY, W., WOODS, H. The Molecular Weights of Proteins. Nature 127, 663–665 (1931). https://doi.org/10.1038/127663b0
Issue Date:
DOI: https://doi.org/10.1038/127663b0
This article is cited by
-
Nature of the Linkages in Proteins
Nature (1937)
-
�ber den Aufbau der Eiwei�molek�le
Kolloid-Zeitschrift (1937)
-
X-Ray Photographs of Crystalline Pepsin
Nature (1934)
-
Neuere Untersuchungen über die Anwendung von Enzymen zur Konstitutionsermittlung der Proteine
Ergebnisse der Physiologie und Experimentellen Pharmakologie (1933)
-
Recent advances in the chemistry of certain blood constituents
Ergebnisse der Physiologie und Experimentellen Pharmakologie (1933)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.