Societies and Academies

    Abstract

    LONDON. Royal Society, Feb. 12.—J. Cohen, K. Cooper, and P. G. Marshall: Some aliphatic and aromatic amino derivatives of α-quinoline methodide. Many of the amino and acylamino compounds obtained by the condensation of derivatives of α-methyl quinoline with nitrosoarylamines possess active antiseptic and in some cases mild trypanocidal properties. Substances obtained by attaching a basic aliphatic or aromatic side-chain directly to the α-carbon of the quinoline nucleus exhibited no marked antiseptic or trypanocidal character. Diamino compounds of aliphatic and aromatic series with basic groups at both ends of the chain did not exhibit the expected anti-malarial action.—C. H. Browning, J. B. Cohen, S. Ellingworth, and R. Gulbransen: The antiseptic and trypanoidal action of certain styryl and anil benzthiazole derivatives. The anil benzthiazole derivatives are relatively weakly antiseptic for Staphylococcus and B. coli, as compared with the quinoline analogues, which are highly aqtive in this respect. Several benzthiazole styryl compounds have produced cure of mice infected with Trypanosoma brucei, and the same relationships between chemical constitution and trypanocidal action have been found to hold as in the styryl quinoline series. Thus the maximum effect is produced when one nucleus contains a basic group and the other an acetylamino group. The anil benzthiazole series, in general, possesses some trypanocidal action, but cure has only exceptionally been produced.

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    Societies and Academies. Nature 127, 293–295 (1931). https://doi.org/10.1038/127293a0

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