The Ovary Stimulating Hormone of the Placenta

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THE production of prematurity in young female rats and mice by Smith and Engle in America, and by Zondek and Aschheim in Germany, through the use of the anterior pituitary gland transplant or emulsion has afforded a great stimulus to further investigation of the hormonal control of gonadal activity. The latter investigators have demonstrated that effects somewhat similar to those following pituitary gland implantations can be elicited in immature rats and mice by extract of pregnancy urine which has been rendered œstrin-free. They have likewise shown decidua, placenta, the corpus luteum of pregnancy, as well as pregnancy blood, to contain an ovary stimulatory hormone analogous to that of the anterior pituitary gland.

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