Mass and Size of Protein Molecules


BY means of a method which utilises the measurement of sedimentation equilibrium and sedimentation velocity in strong centrifugal fields at constant temperature, a systematic study of the mass and size properties of the molecules of various proteins has been carried out in this laboratory during the last five years. Our work has been rewarded by the discovery of a most unexpected and striking general relationship between the mass of the molecules of different proteins and the mass of the molecules of the same protein at different acidities, as well as of a relationship concerning the size and shape of the protein molecules.

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SVEDBERG, T. Mass and Size of Protein Molecules. Nature 123, 871 (1929).

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