Table 1 High-level amplifications (log 2 ratio>2.0) detected in OSCC cell lines by array-CGH analysis using MCG Cancer Array-800 and Whole Genome Array-4500

From: PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation

No BAC Locus a Cell line (total 18) Possible candidate gene b Number of known gene
   Chromosome band Position n Name   
1 RP11-123P3
RP11-433J22
1q21 chr1:144,160,737-144,316,863
chr1:144,332,334-144,519,348
1 HSC-7
HSC-7
BCL9 38
2 RP11-444P10
RP11-215K24
RP11-90H15
RP11-154H23
3p13 chr3:69,701,828-69,903,040
chr3:70,082,272-70,235,455
chr3:71,172,843-71,304,638
chr3:71,622,959-71,816,508
1 HSC-7 MITF 20
3 RP11-14K11
RP11-339F13
RP11-97P11
RP11-34J24
7p11.2 chr7:54,903,388-54,903,650
chr7:55,029,594-55,154,846
chr7:55,238,305-55,381,999
chr7:55,274,090-55,403,627
4 ZA, NA, HSC-2, KON EGFR 9
4 RP11-120E20 11p15.4 chr11:3,573,460-3,758,006 1 OM-1   62
5 RP11-350M7 11p15.2 chr11:13,284,758-13,494,094 1 HSC-6 PTH 8
6 RP11-300I6
CTD-2234J21
RP11-804L21
11q13.3 chr11:69,162,462-69,323,966
chr11:69,307,612-69,307,884
1 OM-1 BCL1, FGF4, CCND1, FGF3 40
7 RP11-681O17
RP11-111A13
RP11-864G5
RP11-315O6
RP11-750P5
RP11-2I22
11q22 chr11:100,365,386-100,536,934
chr11:101,517,505-101,686,954
chr11:101,600,598-101,786,581
chr11:101,724,636-101,939,137
chr11:102,010,611-102,191,046
chr11:102,613,696-102,771,594
1 TSU PGR, YAP1, CIAP1, MMP7, MMP1 31
8 RP11-117K21 11q23.3 chr11:119,773,356-119,939,639 2 OM-1, NA   3
9 CTD-2058B01
RP11-24N12
RP11-88D16
RP11-74M9
RP11-388F6
12p13 chr12:2,977,826-3,145,569
chr12:3,295,578-3,473,577
chr12:4,177,493-4,279,837
chr12:4,313,654-4,483,853
1 HSC-7 CCND2, FGF6 33
10 RP11-87C12
RP11-512 M8
12q24.31 chr12:120,771,781-120,958,360
chr12:121,153,004-121,339,958
1 HSC-5 BCL7A 56
11 RP11-313L9
RP11-91C11
RP11-230F18
RP11-51H10
13q33.3–q34 chr13:109,059,437-109,253,923
chr13:110,332,616-110,333,140
chr13:113,193,310-113,252,507
chr13:113,492,714-113,658,045
1 HSC-7 DP1, GAS6  
12 RP11-74 M3
RP11-59 M15
RP11-72J8
RP11-18G18
14q24.1 chr14:68,410,041-68,581,432
chr14:69,101,595-69,152,329
chr14:69,266,041-69,440,807
chr14:69,652,605-69,652,944
1 NA   25
13 RP11-91H20
RP11-140E1
RP11-118P21
RP11-446K10
RP11-67A5
RP11-256O9
19q13 chr19:43,015,766-43,182,195
chr19:43,372,949-43,537,375
chr19:43,861,826-43,880,848
chr19:44,156,778-44,353,574
chr19:44,449,022-44,620,150
chr19:44,586,344-44,776,946
1 SKN-3 SUPT5H 99
14 RP11-89A2
RP11-29I20
22q12.1 chr22:24,445,961-24,605,516
chr22:24,942,081-24,951,525
1 HSC-7   13
  1. Abbreviations: Array-CGH, array-based comparative genomic hybridization; BAC, bacterial artificial chromosome; OSCC, oral squamous-cell carcinoma.
  2. aBased on UCSC Genome Browser, May 2004 Assembly.
  3. bRepresentative candidate oncogene located around BAC.